TSKU

Across TCGA pan-cancer cohorts, TSKU RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TSKU’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TSKU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TSKU is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where TSKU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TSKU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.255	<.001	10	view →
LUAD	Female	II,III,IV	+1.881	<.001	9	view →
LUSC	Male	II,III,IV	+2.223	<.001	8	view →
KICH	All	II,III,IV	−1.421	.001	7	view →
UCEC	All	III,IV	+1.288	.003	4	view →
BRCA	All	All	−0.367	.010	4	view →
CHOL	All	All	−2.599	<.001	3	view →
LIHC	Female	II,III,IV	−1.736	.005	3	view →
KIRP	All	II,III,IV	+1.448	.007	3	view →
STAD	Male	II,III,IV	+0.894	.011	3	view →
READ	Female	All	+0.772	.006	1	view →
COAD	Male	II,III,IV	+0.429	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TSKU–HNSC

Open the HNSC breakdown →