TRPM3

Across TCGA patient cohorts, TRPM3 mutation is significantly associated with the RNA expression of many other genes, with 7,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRPM3-associated genes across cancer lineages are AURKB, FAM136A, and RCC1. Each is linked with TRPM3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TRPM3-to-partner and partner-to-TRPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AURKB grouped by TRPM3-low versus TRPM3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRPM3→partner) and Y-score (partner→TRPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	AURKB →	+0.484	+3.918	.003	<.001	3	6
CESC	FAM136A →	+0.584	+2.528	<.001	.009	1	8
UCEC	RCC1 →	+0.365	+1.166	<.001	<.001	3	6
STAD	PTTG1 →	+0.611	+2.725	.004	.002	3	6
LUAD	STOML2 →	+0.394	+2.427	.002	<.001	3	6
UCEC	PIMREG →	+0.600	+1.272	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,962 associations by consensus.

AURKB by TRPM3 expression — LUSC

Explore this box plot interactively →