TRIM60

Across TCGA patient cohorts, TRIM60 mutation is significantly associated with the RNA expression of many other genes, with 559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM60-associated genes across cancer lineages are RNU6-1214P, LINC02810, and FAM8A2P. Each is linked with TRIM60 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM60-to-partner and partner-to-TRIM60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1214P grouped by TRIM60-low versus TRIM60-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM60→partner) and Y-score (partner→TRIM60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1214P →	+0.425	+5.306	<.001	.006	3	3
HNSC	LINC02810 →	+0.072	+4.536	.007	.005	3	3
CESC	FAM8A2P →	+0.056	+5.539	<.001	.004	3	2
CESC	NF1P10 →	+0.235	+6.569	<.001	.001	3	2
HNSC	FSHB →	+0.020	+4.578	.009	.008	3	2
HNSC	RNA5SP378 →	+0.425	+4.536	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

RNU6-1214P by TRIM60 expression — CESC

Explore this box plot interactively →