TRIM6-TRIM34

Across TCGA cell cohorts, TRIM6-TRIM34 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM6-TRIM34-associated genes across cancer lineages are TRIM64B, TCEAL6, and LY6G6F. Each is linked with TRIM6-TRIM34 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM6-TRIM34-to-partner and partner-to-TRIM6-TRIM34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64B grouped by TRIM6-TRIM34-low versus TRIM6-TRIM34-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6-TRIM34→partner) and Y-score (partner→TRIM6-TRIM34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRIM64B →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TCEAL6 →	+0.074	+4.467	<.001	.004	3	1
LARGE_INTESTINE	LY6G6F →	+0.229	+4.467	<.001	.004	3	1
LARGE_INTESTINE	KCNU1 →	+0.063	+4.930	<.001	.001	3	1
LARGE_INTESTINE	KRTAP7-1 →	+0.060	+5.022	<.001	.002	3	1
SKIN	C10orf71 →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TRIM64B by TRIM6-TRIM34 expression — LARGE_INTESTINE

Explore this box plot interactively →