TRIM6-TRIM34

Across TCGA pan-cancer cohorts, TRIM6-TRIM34 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRIM6-TRIM34’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TRIM6-TRIM34 RNA is repressed in tumor relative to normal tissue. In most cancer types TRIM6-TRIM34 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KICH, PRAD, and KIRP are the cancer types where TRIM6-TRIM34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM6-TRIM34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.032	.043	2	view →
PRAD	All	All	−0.004	.034	2	view →
KIRP	All	All	−0.018	.036	1	view →
THCA	Female	All	+0.007	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRIM6-TRIM34–KICH

Open the KICH breakdown →