TRIM6-TRIM34

Across TCGA pan-cancer cohorts, TRIM6-TRIM34 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated TRIM6-TRIM34 data layer compared with 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRIM6-TRIM34 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM6-TRIM34 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRC show a favorable association.

LUAD, BLCA, and COAD are the cancer types where TRIM6-TRIM34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.607	0.817	<.001	69	view →
BLCA	DFS	Tertile	IV	0.535	0.171	.014	48	view →
COAD	DFS	Tertile	III,IV	0.244	0.672	.003	36	view →
GBM	OS	Tertile	All	0.206	0.431	.001	27	view →
LIHC	OS	Tertile	All	0.537	0.795	.003	27	view →
KIRC	DFS	Tertile	II,III,IV	0.777	0.544	.012	20	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	18	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →
READ	DFS	Tertile	III,IV	0.027	0.761	<.001	18	view →
UCEC	DFS	Tertile	II,III,IV	0.287	0.741	.002	18	view →
SCLC	OS	Tertile	All	1.000	0.590	.031	12	view →
BRCA	OS	Tertile	All	0.437	0.611	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

TRIM6-TRIM34–LUAD (OS)

Open the LUAD breakdown →