TRIM55

Across TCGA patient cohorts, TRIM55 mutation is significantly associated with the RNA expression of many other genes, with 1,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM55-associated genes across cancer lineages are GINS2, ACRBP, and TRAIP. Each is linked with TRIM55 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM55-to-partner and partner-to-TRIM55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS2 grouped by TRIM55-low versus TRIM55-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM55→partner) and Y-score (partner→TRIM55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS2 →	+0.856	+3.459	<.001	.005	3	4
COAD	ACRBP →	+0.632	+3.335	.003	.005	3	3
COAD	TRAIP →	+0.465	+3.210	.005	.009	3	3
UCEC	GINS3 →	+0.522	+1.928	.001	.009	3	3
SKCM	NCKIPSD →	+0.340	+2.100	.001	.002	3	3
SKCM	CDC7 →	+0.457	+1.746	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,025 associations by consensus.

GINS2 by TRIM55 expression — UCEC

Explore this box plot interactively →