TRIM55

Across TCGA pan-cancer cohorts, TRIM55 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRIM55 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRIM55 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRIM55 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRP show a favorable association.

SKCM, KIRP, and BLCA are the cancer types where TRIM55 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.686	0.553	<.001	85	view →
KIRP	OS	Quartile	All	0.963	0.818	.002	82	view →
BLCA	OS	Median	All	0.539	0.239	<.001	68	view →
KIRC	DFS	Median	All	0.698	0.556	<.001	61	view →
LIHC	OS	Tertile	II,III,IV	0.729	0.376	.001	42	view →
LUAD	OS	Tertile	All	0.754	0.623	.004	32	view →
LUSC	OS	Median	All	0.327	0.460	.001	29	view →
ESCA	DFS	Quartile	III,IV	0.545	0.253	.011	28	view →
HNSC	OS	Median	II,III,IV	0.284	0.495	.003	27	view →
PCPG	DFS	Tertile	All	0.537	1.000	.001	27	view →
CHOL	DFS	Quartile	II,III,IV	0.171	0.630	.014	12	view →
ACC	OS	Median	II,III,IV	0.862	0.649	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRIM55–SKCM (DFS)

Open the SKCM breakdown →