TRIM43

Across TCGA cell cohorts, TRIM43 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TRIM43-associated genes across cancer lineages are TAAR5, OR10K1, and CLEC2A. Each is linked with TRIM43 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM43-to-partner and partner-to-TRIM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR5 grouped by TRIM43-low versus TRIM43-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM43→partner) and Y-score (partner→TRIM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAAR5 →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	OR10K1 →	+0.467	+5.029	<.001	.006	3	1
LUNG_SCLC	CLEC2A →	+0.129	+5.029	<.001	.006	3	1
LUNG_SCLC	DUSP21 →	+0.031	+5.029	<.001	.006	3	1
LUNG_SCLC	OR11G2 →	+0.030	+5.643	<.001	.002	3	1
LUNG_SCLC	OR6Y1 →	+0.006	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TAAR5 by TRIM43 expression — LUNG_SCLC

Explore this box plot interactively →