TRIM43

Across TCGA pan-cancer cohorts, TRIM43 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TRIM43 data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TRIM43 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM43 expression acts as an unfavorable survival marker, although some lineages such as LAML and LGG show a favorable association.

BLCA, UVM, and MESO are the cancer types where TRIM43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.215	0.539	<.001	132	view →
UVM	OS	Tertile	All	0.337	0.816	<.001	45	view →
MESO	DFS	Tertile	IV	0.130	0.405	.019	36	view →
KIRC	OS	Tertile	All	0.473	0.675	.009	24	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
SCLC	OS	Tertile	IV	0.137	0.556	.025	18	view →
CESC	DFS	Tertile	II,III,IV	0.459	0.733	.042	18	view →
PCPG	DFS	Tertile	All	0.420	0.857	.019	18	view →
THCA	OS	Tertile	All	0.977	0.993	.024	12	view →
LAML	DFS	Tertile	All	0.757	0.341	.043	12	view →
SKCM	DFS	Tertile	IV	0.047	0.470	.036	9	view →
BRCA	DFS	Tertile	IV	0.436	0.763	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

TRIM43–BLCA (DFS)

Open the BLCA breakdown →