TRIM43

Across TCGA pan-cancer cohorts, TRIM43 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRIM43’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TRIM43 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM43 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

LUSC, UCEC, and BRCA are the cancer types where TRIM43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.080	.019	3	view →
UCEC	All	All	+0.341	.018	2	view →
BRCA	All	III,IV	−0.061	.027	2	view →
LUAD	Male	All	+0.026	.027	2	view →
STAD	All	All	+0.025	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRIM43–LUSC

Open the LUSC breakdown →