TRIM16L

Across TCGA patient cohorts, TRIM16L mutation is significantly associated with the RNA expression of many other genes, with 1,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM16L-associated genes across cancer lineages are DEFB117, LINC01766, and MIR4499. Each is linked with TRIM16L in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM16L-to-partner and partner-to-TRIM16L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB117 grouped by TRIM16L-low versus TRIM16L-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM16L→partner) and Y-score (partner→TRIM16L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DEFB117 →	+0.272	+4.496	<.001	.007	3	2
SKCM	LINC01766 →	+0.326	+3.838	<.001	.009	3	2
CESC	MIR4499 →	+0.346	+4.969	<.001	.004	3	2
CESC	TEKT4P3 →	+0.127	+5.569	<.001	.002	3	2
LUSC	RPS15AP27 →	+0.166	+4.265	.004	.003	3	2
LUSC	PTP4A1P7 →	+0.312	+3.902	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,234 associations by consensus.

DEFB117 by TRIM16L expression — LUSC

Explore this box plot interactively →