TRIM16L

Across TCGA pan-cancer cohorts, TRIM16L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TRIM16L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TRIM16L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM16L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, THCA, and KIRC are the cancer types where TRIM16L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM16L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+2.078	<.001	11	view →
THCA	Male	III,IV	−1.572	<.001	11	view →
KIRC	All	III,IV	+0.458	<.001	11	view →
LIHC	Male	II,III,IV	+2.772	<.001	8	view →
LUSC	Male	II,III,IV	+2.177	<.001	6	view →
KICH	Female	II,III,IV	−1.077	<.001	6	view →
LUAD	All	All	+0.667	<.001	5	view →
CHOL	All	All	+1.586	.011	3	view →
READ	All	II,III,IV	−0.629	.009	3	view →
HNSC	All	II,III,IV	+0.579	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TRIM16L–KIRP

Open the KIRP breakdown →