TRIM16L

Across TCGA pan-cancer cohorts, TRIM16L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRIM16L data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TRIM16L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM16L expression acts as an unfavorable survival marker, although some lineages such as LGG and READ show a favorable association.

UVM, LGG, and READ are the cancer types where TRIM16L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.334	0.822	<.001	83	view →
LGG	DFS	Median	All	0.487	0.312	<.001	54	view →
READ	OS	Median	II,III,IV	0.851	0.449	.004	50	view →
LIHC	OS	Quartile	All	0.584	0.777	<.001	47	view →
KICH	OS	Tertile	All	0.634	1.000	.007	46	view →
LUAD	DFS	Quartile	All	0.718	0.849	.003	37	view →
OV	OS	Tertile	IV	0.589	0.267	<.001	36	view →
THCA	DFS	Tertile	IV	0.433	0.787	.007	34	view →
BRCA	OS	Tertile	IV	0.610	0.177	.021	26	view →
SCLC	DFS	Median	II,III,IV	0.778	0.245	.004	25	view →
KIRC	DFS	Median	All	0.878	0.719	.002	23	view →
ACC	DFS	Tertile	II,III,IV	0.134	0.794	.006	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRIM16L–UVM (DFS)

Open the UVM breakdown →