T cell receptor alpha variable 8-7 (pseudogene)Genealiases: TCRAV8S7 · TRAV87
Q-omics provides the consensus-scored TRAV8-7 profile across patient tissues and cancer cell-line models. TRAV8-7 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, TRAV8-7 is differentially expressed in 4, with the highest sampling consensus in COAD. Additionally, TRAV8-7 RNA expression shows 6,127 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight LIHC, COAD, and THYM as cancer lineages where TRAV8-7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TRAV8-7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TRAV8-7 survival associations across molecular data types. TRAV8-7 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TRAV8-7 RNA expression–survival associations across cancer types. High TRAV8-7 expression shows unfavorable associations in LIHC, UCEC, ESCA, KIRC and CHOL, but favorable associations in LAML. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for TRAV8-7 RNA expression.
This table summarizes TRAV8-7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for TRAV8-7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TRAV8-7 shows lower tumor expression in COAD and higher tumor expression in HNSC, KIRC and LUSC. The COAD box plot shows higher TRAV8-7 RNA expression in normal versus tumor tissue (log2 FC = −0.068, t-test p = .008).
This table shows molecular features associated with TRAV8-7 in patient tissues and cancer cell lines. In patient samples, TRAV8-7 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
