Across TCGA pan-cancer cohorts, TRAV8-7 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAV8-7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRAV8-7 RNA is repressed in tumor relative to normal tissue. In most cancer types TRAV8-7 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where TRAV8-7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV8-7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.068	.008	6	view →
HNSC	Female	III,IV	+0.172	.020	4	view →
KIRC	Male	All	+0.071	.001	4	view →
LUSC	All	All	+0.035	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAV8-7 RNA expression & survival · all TRAV8-7 data types