TRAV1-1

Across TCGA patient cohorts, TRAV1-1 mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRAV1-1-associated genes across cancer lineages are RNU4-73P, MIR6793, and LINC02338. Each is linked with TRAV1-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV1-1-to-partner and partner-to-TRAV1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-73P grouped by TRAV1-1-low versus TRAV1-1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV1-1→partner) and Y-score (partner→TRAV1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU4-73P →	+0.399	+4.984	<.001	.009	3	2
SKCM	MIR6793 →	+0.577	+2.279	.001	.009	3	1
SKCM	LINC02338 →	+0.122	+3.059	<.001	<.001	3	1
SKCM	AQP7P5 →	+0.117	+3.980	<.001	<.001	3	1
UCEC	RNU6-888P →	+0.798	+4.003	<.001	.005	3	1
UCEC	RNY1P1 →	+0.539	+4.750	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

RNU4-73P by TRAV1-1 expression — LUSC

Explore this box plot interactively →