TRAV1-1

Across TCGA pan-cancer cohorts, TRAV1-1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRAV1-1 data layer compared with 3 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRAV1-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRAV1-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where TRAV1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.421	0.278	<.001	126	view →
HNSC	DFS	Median	III,IV	0.403	0.212	.001	72	view →
UVM	DFS	Tertile	All	0.361	0.826	<.001	62	view →
LGG	OS	Tertile	All	0.225	0.467	<.001	42	view →
LUAD	DFS	Median	All	0.860	0.764	.003	39	view →
LIHC	DFS	Median	III,IV	0.601	0.267	.009	23	view →
THCA	OS	Quartile	II,III,IV	0.954	1.000	.005	22	view →
ESCA	DFS	Tertile	III,IV	0.561	0.210	.001	21	view →
BLCA	OS	Quartile	IV	0.813	0.263	.001	19	view →
KICH	DFS	Tertile	II,III,IV	0.480	0.945	.019	18	view →
SARC	OS	Median	All	0.605	0.441	.004	17	view →
UCEC	OS	Median	III,IV	0.717	0.423	.019	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRAV1-1–SKCM (OS)

Open the SKCM breakdown →