TRAV1-1

Across TCGA pan-cancer cohorts, TRAV1-1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAV1-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV1-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV1-1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, BRCA, and LUAD are the cancer types where TRAV1-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV1-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	+0.589	<.001	11	view →
BRCA	All	All	+0.227	<.001	4	view →
LUAD	Female	All	+0.315	.020	2	view →
THCA	All	All	−0.295	.007	2	view →
PRAD	All	All	+0.261	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRAV1-1–KIRC

Open the KIRC breakdown →