TOP2A

Across TCGA patient cohorts, TOP2A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOP2A-associated genes across cancer lineages are Rab25, Di-Ras3, and eEF2. Each is linked with TOP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TOP2A-to-partner and partner-to-TOP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by TOP2A-low versus TOP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2A→partner) and Y-score (partner→TOP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.358	-1.652	.001	.006	3	2
UCEC	Di-Ras3 →	-0.172	-2.263	<.001	<.001	3	2
UCEC	eEF2 →	+0.312	+2.000	.008	.029	3	2
UCEC	EGFR_pY1068 →	-0.305	-2.263	<.001	<.001	3	2
UCEC	GAPDH →	+0.351	+2.000	.047	.029	3	2
UCEC	PKC-delta_pS664 →	-0.087	-2.700	.027	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Rab25 by TOP2A expression — UCEC

Explore this box plot interactively →