TOP2A

Across TCGA cell cohorts, TOP2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,518 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOP2A-associated GO terms across cancer lineages are Immunoglobulin heavy chain V-D-J recombination, Nuclear division, and Spindle elongation. Each is linked with TOP2A in more than 19 cancer types. Because this analysis shows association rather than direction, both TOP2A-to-partner and partner-to-TOP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin heavy chain V-D-J recombination grouped by TOP2A-low versus TOP2A-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOP2A→partner) and Y-score (partner→TOP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Immunoglobulin heavy chain V-D-J recombination →	+0.263	+1.682	<.001	<.001	3	20
OESOPHAGUS	Nuclear division →	+0.104	+1.391	<.001	<.001	3	20
SOFT_TISSUE	Spindle elongation →	+0.223	+0.886	<.001	<.001	3	20
BLOOD_Myeloma	Meiotic cell cycle →	+0.076	+1.524	.005	.002	3	20
BREAST	Regulation of mitotic nuclear division →	+0.129	+1.134	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic cell cycle checkpoint signaling →	+0.110	+1.681	.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,518 associations by consensus.

Immunoglobulin heavy chain V-D-J recombination by TOP2A expression — OESOPHAGUS

Explore this box plot interactively →