TOM1

Across TCGA cell cohorts, TOM1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOM1-associated genes across cancer lineages are MS4A10, OR11L1, and VN1R4. Each is linked with TOM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOM1-to-partner and partner-to-TOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by TOM1-low versus TOM1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOM1→partner) and Y-score (partner→TOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MS4A10 →	+0.006	+6.357	<.001	<.001	3	1
CNS	OR11L1 →	+0.031	+4.981	<.001	.008	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LARGE_INTESTINE	OR2D3 →	+0.018	+2.925	.006	.007	3	1
LARGE_INTESTINE	SAMD7 →	+0.014	+2.878	.002	.009	3	1
LARGE_INTESTINE	CLDN34 →	+0.064	+3.655	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MS4A10 by TOM1 expression — CNS

Explore this box plot interactively →