TOM1

Across TCGA pan-cancer cohorts, TOM1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TOM1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TOM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TOM1 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

LIHC, HNSC, and THCA are the cancer types where TOM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+0.840	<.001	9	view →
HNSC	Male	II,III,IV	−0.566	<.001	8	view →
THCA	Male	III,IV	−0.408	<.001	7	view →
KICH	All	II,III,IV	+0.424	.006	5	view →
LUSC	All	All	−0.334	<.001	5	view →
CHOL	Male	All	+1.148	<.001	3	view →
BLCA	Male	All	+0.471	.018	3	view →
LUAD	Male	All	−0.240	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TOM1–LIHC

Open the LIHC breakdown →