TNIP1

Across TCGA patient cohorts, TNIP1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TNIP1-associated genes across cancer lineages are PDCD4, ATM, and BRCA2. Each is linked with TNIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TNIP1-to-partner and partner-to-TNIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TNIP1-low versus TNIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TNIP1→partner) and Y-score (partner→TNIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.435	-3.321	.010	.009	3	2
UCEC	ATM →	-0.492	-2.321	.002	.001	3	2
UCEC	BRCA2 →	-0.147	-2.404	.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.687	+1.926	.001	.008	3	2
UCEC	eEF2 →	+0.402	+2.807	.001	.003	3	1
UCEC	eIF4E →	+0.175	+1.750	.021	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PDCD4 by TNIP1 expression — UCEC

Explore this box plot interactively →