TNIP1

Across TCGA pan-cancer cohorts, TNIP1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TNIP1 data layer compared with 10 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TNIP1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TNIP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and LGG are the cancer types where TNIP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.741	0.513	<.001	121	view →
BRCA	OS	Median	All	0.618	0.529	.001	52	view →
LGG	DFS	Tertile	All	0.637	0.845	<.001	47	view →
UCEC	DFS	Tertile	All	0.890	0.799	.007	42	view →
LIHC	OS	Median	All	0.387	0.706	.001	20	view →
MESO	DFS	Median	IV	0.206	0.507	.003	18	view →
LUAD	OS	Tertile	All	0.753	0.848	.011	18	view →
COAD	OS	Median	III,IV	0.902	0.671	.002	16	view →
LUSC	DFS	Quartile	All	0.373	0.587	.007	16	view →
CHOL	OS	Quartile	II,III,IV	0.770	0.212	.022	16	view →
BLCA	DFS	Median	All	0.672	0.573	.022	13	view →
KIRP	DFS	Quartile	II,III,IV	0.598	0.925	.012	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TNIP1–KIRC (OS)

Open the KIRC breakdown →