TNIP1

Across TCGA pan-cancer cohorts, TNIP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TNIP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TNIP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TNIP1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where TNIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TNIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.395	<.001	12	view →
LIHC	All	II,III,IV	+1.060	<.001	9	view →
KICH	Male	All	−0.907	<.001	8	view →
COAD	Female	II,III,IV	−0.568	<.001	7	view →
BRCA	All	II,III,IV	−0.689	<.001	6	view →
LUSC	All	All	−0.362	<.001	6	view →
THCA	All	II,III,IV	+0.216	.004	6	view →
HNSC	All	II,III,IV	+0.285	.007	4	view →
CHOL	All	All	+1.321	<.001	3	view →
READ	Female	All	−0.656	.016	2	view →
STAD	All	All	+0.363	.030	2	view →
PRAD	All	All	−0.196	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TNIP1–KIRC

Open the KIRC breakdown →