Across TCGA patient cohorts, TMPRSS11B mutation is significantly associated with the RNA expression of many other genes, with 4,395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMPRSS11B-associated genes across cancer lineages are CHEK1, PIGF, and HOMER1. Each is linked with TMPRSS11B in more than 2 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.859	+2.606	<.001	<.001	3	3
UCEC	PIGF →	+0.424	+2.839	.001	.001	3	3
UCEC	HOMER1 →	+0.573	+2.332	.002	.003	3	3
UCEC	SKA1 →	+0.969	+3.010	<.001	<.001	3	3
SKCM	SASS6 →	+0.582	+2.189	<.001	.001	3	3
UCEC	BUB1B →	+0.899	+2.148	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,395 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types