Across TCGA pan-cancer cohorts, TMPRSS11B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TMPRSS11B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMPRSS11B RNA is repressed in tumor relative to normal tissue. In most cancer types TMPRSS11B is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where TMPRSS11B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMPRSS11B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−5.370	<.001	12	view →
LUSC	Male	All	+0.616	<.001	4	view →
LUAD	Male	II,III,IV	+0.013	.046	1	view →
THCA	All	II,III,IV	−0.009	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TMPRSS11B RNA expression & survival · all TMPRSS11B data types