Across TCGA cell cohorts, TMPRSS11B mutation is significantly associated with the mutation status of many other genes, with 2,880 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMPRSS11B-associated genes across cancer lineages are UNC13D, MAP3K5, and TDRD1. Each is linked with TMPRSS11B in more than 4 cancer types. Because this analysis shows association rather than direction, both TMPRSS11B-to-partner and partner-to-TMPRSS11B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMPRSS11B→partner) and Y-score (partner→TMPRSS11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC13D →	+3.329	+3.799	.005	.005	1	5
LUNG_NSCLC_LUAD	MAP3K5 →	+4.772	+5.339	.004	.004	1	4
LUNG_NSCLC_LUAD	TDRD1 →	+4.187	+5.000	.008	.008	1	4
BREAST	MYH2 →	+5.297	+5.297	.004	.004	1	4
BLOOD_Leukemia	KCNH6 →	+3.894	+5.247	.001	.001	1	4
BLOOD_Leukemia	MGAM →	+2.672	+4.225	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,880 associations by consensus.

Exploration

TMPRSS11B survival (RNA) · tumor vs normal (RNA) · all TMPRSS11B data types