TMEM45A

Across TCGA patient cohorts, TMEM45A mutation is significantly associated with the RNA expression of many other genes, with 2,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM45A-associated genes across cancer lineages are MIR4510, LINC02563, and SSXP4. Each is linked with TMEM45A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM45A-to-partner and partner-to-TMEM45A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by TMEM45A-low versus TMEM45A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM45A→partner) and Y-score (partner→TMEM45A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.359	+6.342	<.001	.001	3	3
UCEC	LINC02563 →	+0.114	+2.613	.001	.006	3	3
BRCA	SSXP4 →	+0.133	+7.731	<.001	.009	3	2
UCEC	MIR659 →	+0.683	+3.430	.005	.005	3	2
BRCA	RNU6-253P →	+0.282	+8.055	<.001	.007	3	2
BRCA	LINC00363 →	+0.152	+7.731	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,327 associations by consensus.

MIR4510 by TMEM45A expression — CESC

Explore this box plot interactively →