Q-omics provides the consensus-scored RNU6-253P profile across patient tissues and cancer cell-line models. RNU6-253P expression is associated with patient survival in 5 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, RNU6-253P RNA expression shows 3,764 significant gene co-expression associations, with the highest sampling consensus in STAD. Together, these results highlight HNSC, and STAD as cancer lineages where RNU6-253P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes RNU6-253P survival associations across molecular data types. RNU6-253P RNA expression shows survival associations in the most cancer types (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

RNU6-253P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	5	HNSC (78)	view →

This table ranks reproducible RNU6-253P RNA expression–survival associations across cancer types. High RNU6-253P expression shows unfavorable associations in HNSC, PAAD, THCA, KIRC and OV. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for RNU6-253P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.071	0.718	<.001	78	view →
PAAD	OS	Tertile	All	0.175	0.616	<.001	72	view →
THCA	DFS	Tertile	All	0.049	0.828	<.001	54	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
OV	DFS	Tertile	III,IV	0.313	0.535	.014	18	view →

Pink = unfavorable, green = favorable. all 5 lineages →

RNU6-253P-HNSC (OS)

Kaplan–Meier survival curve for RNU6-253P RNA expression in HNSC: high vs low expression groups.

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Cross-omics associations

This table shows molecular features associated with RNU6-253P in patient tissues and cancer cell lines. In patient samples, RNU6-253P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	3,764	STAD (2375)	view →
Function (RNA)	1,325	STAD (1126)	view →