TMEM45A

Across TCGA pan-cancer cohorts, TMEM45A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM45A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM45A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM45A is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.

KIRC, THCA, and LUSC are the cancer types where TMEM45A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM45A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+3.606	<.001	12	view →
THCA	Male	All	−0.986	<.001	8	view →
LUSC	Male	All	+1.524	<.001	6	view →
LIHC	Female	All	−1.513	<.001	6	view →
KICH	Female	All	−1.070	<.001	6	view →
BRCA	Female	II,III,IV	+0.809	<.001	6	view →
HNSC	All	All	+0.978	.015	3	view →
LUAD	All	All	+0.737	.001	3	view →
PRAD	All	All	−0.675	<.001	2	view →
STAD	Male	All	+0.575	.042	2	view →
CHOL	All	All	−1.324	.013	1	view →
READ	Female	All	−0.794	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM45A–KIRC

Open the KIRC breakdown →