TMEM45A

Across TCGA pan-cancer cohorts, TMEM45A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TMEM45A data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TMEM45A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM45A expression acts as an unfavorable survival marker, although some lineages such as DLBC and UVM show a favorable association.

STAD, BRCA, and KICH are the cancer types where TMEM45A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.478	0.716	<.001	112	view →
BRCA	OS	Tertile	All	0.937	0.976	<.001	79	view →
KICH	OS	Tertile	III,IV	0.236	0.885	.002	68	view →
OV	DFS	Median	All	0.479	0.604	<.001	66	view →
KIRP	DFS	Tertile	III,IV	0.307	0.771	.001	63	view →
THCA	OS	Median	III,IV	0.944	1.000	.004	45	view →
LUAD	OS	Tertile	All	0.778	0.893	<.001	34	view →
DLBC	DFS	Quartile	III,IV	0.773	0.066	.006	25	view →
CHOL	OS	Tertile	All	0.153	0.892	.003	20	view →
UVM	OS	Quartile	All	0.925	0.738	.016	19	view →
KIRC	OS	Median	All	0.567	0.690	.003	17	view →
LGG	OS	Median	All	0.866	0.923	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TMEM45A–STAD (OS)

Open the STAD breakdown →