TMEM145

Across TCGA patient cohorts, TMEM145 mutation is significantly associated with the RNA expression of many other genes, with 1,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM145-associated genes across cancer lineages are VN1R90P, LINC02293, and IQCA1L. Each is linked with TMEM145 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM145-to-partner and partner-to-TMEM145 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R90P grouped by TMEM145-low versus TMEM145-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM145→partner) and Y-score (partner→TMEM145) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VN1R90P →	+0.237	+4.993	<.001	.002	3	2
BLCA	LINC02293 →	+0.343	+3.397	.008	.001	3	2
BLCA	IQCA1L →	+0.027	+2.937	.003	.003	3	2
UCEC	BRIX1 →	+0.558	+3.617	.007	.001	3	2
LUAD	RHNO1 →	+0.462	+3.330	.006	.005	3	2
LUAD	ZNF724 →	+0.630	+3.345	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,712 associations by consensus.

VN1R90P by TMEM145 expression — COAD

Explore this box plot interactively →