TMEM145

Across TCGA pan-cancer cohorts, TMEM145 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMEM145 data layer compared with 3 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TMEM145 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM145 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

BRCA, ACC, and LUAD are the cancer types where TMEM145 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.935	0.829	.003	63	view →
ACC	DFS	Quartile	All	0.197	0.673	<.001	51	view →
LUAD	OS	Tertile	All	0.765	0.861	.007	41	view →
OV	OS	Tertile	All	0.640	0.735	.005	36	view →
UCS	DFS	Tertile	IV	0.363	0.942	.024	24	view →
PRAD	DFS	Median	All	0.692	0.863	.008	16	view →
THCA	DFS	Median	III,IV	0.756	0.935	.003	13	view →
KIRC	OS	Tertile	All	0.556	0.709	.011	12	view →
LAML	DFS	Tertile	All	0.286	0.602	.024	12	view →
LGG	OS	Median	All	0.936	0.852	<.001	12	view →
UVM	DFS	Quartile	II,III,IV	0.536	0.855	.016	11	view →
SKCM	DFS	Median	IV	0.674	0.142	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMEM145–BRCA (OS)

Open the BRCA breakdown →