TMEM117

Across TCGA patient cohorts, TMEM117 mutation is significantly associated with the RNA expression of many other genes, with 3,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM117-associated genes across cancer lineages are GPATCH3, RN7SL134P, and SAP30. Each is linked with TMEM117 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM117-to-partner and partner-to-TMEM117 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPATCH3 grouped by TMEM117-low versus TMEM117-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM117→partner) and Y-score (partner→TMEM117) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPATCH3 →	+0.381	+2.971	<.001	<.001	3	3
UCEC	RN7SL134P →	+0.073	+1.899	.007	.002	3	3
UCEC	SAP30 →	+0.582	+2.243	<.001	<.001	3	3
SKCM	RNU6-158P →	+0.194	+2.862	<.001	.005	3	2
HNSC	RNU6-525P →	+0.277	+3.566	<.001	.004	3	2
READ	RNU6-145P →	+0.603	+5.315	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,367 associations by consensus.

GPATCH3 by TMEM117 expression — UCEC

Explore this box plot interactively →