TMEM117

Across TCGA pan-cancer cohorts, TMEM117 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM117 data layer compared with 7 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher TMEM117 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM117 expression acts as an unfavorable survival marker, although some lineages such as LUSC and READ show a favorable association.

MESO, LUSC, and ACC are the cancer types where TMEM117 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.269	0.491	<.001	69	view →
LUSC	DFS	Median	All	0.783	0.709	.008	34	view →
ACC	OS	Median	All	0.794	0.949	.014	23	view →
LUAD	OS	Quartile	All	0.607	0.773	.002	20	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	15	view →
ESCA	DFS	Quartile	II,III,IV	0.206	0.433	.012	15	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	14	view →
STAD	OS	Median	II,III,IV	0.608	0.740	.002	12	view →
KIRP	OS	Quartile	II,III,IV	0.224	0.586	.003	12	view →
SKCM	OS	Median	II,III,IV	0.249	0.379	.004	11	view →
LIHC	DFS	Quartile	All	0.142	0.425	.013	10	view →
LGG	OS	Tertile	All	0.829	0.958	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM117–MESO (OS)

Open the MESO breakdown →