TLE3

Across TCGA patient cohorts, TLE3 mutation is significantly associated with the RNA expression of many other genes, with 1,034 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLE3-associated genes across cancer lineages are FAM41AY1, RNU6-642P, and LINC00869. Each is linked with TLE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLE3-to-partner and partner-to-TLE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM41AY1 grouped by TLE3-low versus TLE3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE3→partner) and Y-score (partner→TLE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM41AY1 →	+0.026	+5.741	<.001	<.001	3	3
UCEC	RNU6-642P →	+0.179	+2.242	<.001	.005	3	3
UCEC	LINC00869 →	-0.560	-2.297	<.001	.006	3	2
COAD	KPNA2P1 →	+0.123	+3.592	.009	.003	3	2
READ	RNU6-522P →	+0.916	+5.681	<.001	.001	3	2
READ	RPL22P21 →	+0.117	+4.421	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,034 associations by consensus.

FAM41AY1 by TLE3 expression — COAD

Explore this box plot interactively →