TLE3

Across TCGA pan-cancer cohorts, TLE3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TLE3 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TLE3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TLE3 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, COAD, and BRCA are the cancer types where TLE3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.706	0.217	<.001	68	view →
COAD	DFS	Median	II,III,IV	0.292	0.754	<.001	45	view →
BRCA	DFS	Quartile	III,IV	0.925	0.766	.001	43	view →
ACC	DFS	Tertile	All	0.222	0.653	.001	38	view →
UCEC	DFS	Median	III,IV	0.847	0.735	.006	24	view →
LIHC	DFS	Quartile	All	0.453	0.619	.004	23	view →
LUSC	DFS	Tertile	III,IV	0.330	0.935	.003	19	view →
KIRC	DFS	Tertile	All	0.859	0.716	.013	18	view →
CESC	OS	Quartile	All	0.917	0.777	.006	10	view →
LGG	OS	Quartile	All	0.951	0.802	.001	9	view →
MESO	OS	Quartile	II,III,IV	0.291	0.511	.020	9	view →
PAAD	DFS	Tertile	II,III,IV	0.552	0.357	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TLE3–UCS (DFS)

Open the UCS breakdown →