TIPIN

Across TCGA patient cohorts, TIPIN mutation is significantly associated with the RNA expression of many other genes, with 2,889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIPIN-associated genes across cancer lineages are RNA5SP412, RNU6-197P, and RNA5SP413. Each is linked with TIPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPIN-to-partner and partner-to-TIPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by TIPIN-low versus TIPIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPIN→partner) and Y-score (partner→TIPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.591	+2.189	<.001	.002	3	2
SKCM	RNU6-197P →	+0.645	+4.979	<.001	.009	3	2
UCEC	RNA5SP413 →	+1.328	+2.736	<.001	<.001	3	2
UCEC	RNA5SP422 →	+1.131	+2.823	<.001	<.001	3	2
BRCA	MIR31 →	+0.775	+6.112	<.001	.002	3	1
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

RNA5SP412 by TIPIN expression — UCEC

Explore this box plot interactively →