TIPIN

Across TCGA pan-cancer cohorts, TIPIN RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of TIPIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TIPIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIPIN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where TIPIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIPIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.074	<.001	12	view →
BLCA	Male	III,IV	+1.057	<.001	11	view →
STAD	Male	II,III,IV	+1.188	<.001	9	view →
COAD	Female	II,III,IV	+1.082	<.001	9	view →
LIHC	Male	All	+0.944	<.001	9	view →
LUSC	Female	All	+1.212	<.001	8	view →
KIRP	All	II,III,IV	+0.593	.001	8	view →
LUAD	All	II,III,IV	+0.587	<.001	8	view →
UCEC	All	All	+0.488	.005	6	view →
BRCA	All	II,III,IV	+0.442	<.001	6	view →
CHOL	All	II,III,IV	+1.804	<.001	5	view →
KICH	Female	All	−0.834	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

TIPIN–HNSC

Open the HNSC breakdown →