TIPIN

Across TCGA pan-cancer cohorts, TIPIN RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TIPIN data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TIPIN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIPIN expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KICH, KIRC, and LIHC are the cancer types where TIPIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	All	0.531	1.000	.001	72	view →
KIRC	DFS	Quartile	All	0.880	0.760	<.001	66	view →
LIHC	DFS	Median	All	0.449	0.634	<.001	57	view →
UVM	DFS	Quartile	III,IV	0.232	0.832	.005	54	view →
BLCA	OS	Median	All	0.652	0.786	.001	49	view →
ACC	DFS	Quartile	All	0.207	0.746	<.001	48	view →
LGG	DFS	Median	All	0.772	0.893	<.001	47	view →
READ	DFS	Median	All	0.668	0.278	.008	33	view →
LUSC	OS	Tertile	All	0.480	0.308	.003	30	view →
KIRP	DFS	Quartile	All	0.822	0.973	.004	26	view →
LUAD	OS	Tertile	All	0.761	0.866	.003	24	view →
THYM	OS	Median	All	0.956	0.593	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TIPIN–KICH (DFS)

Open the KICH breakdown →