TIMM8B

Across TCGA patient cohorts, TIMM8B mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM8B-associated genes across cancer lineages are AQP7P4, RNU105C, and RNU6-839P. Each is linked with TIMM8B in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM8B-to-partner and partner-to-TIMM8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P4 grouped by TIMM8B-low versus TIMM8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM8B→partner) and Y-score (partner→TIMM8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P4 →	+0.122	+5.027	<.001	.004	3	2
UCEC	RNU105C →	+0.205	+4.484	.002	.009	3	2
BLCA	RNU6-839P →	+0.313	+7.640	<.001	.009	3	1
BLCA	RN7SKP6 →	+0.119	+7.640	<.001	.009	3	1
BLCA	MIR521-1 →	+0.367	+7.640	<.001	.009	3	1
UCEC	BCRP6 →	+0.166	+4.661	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

AQP7P4 by TIMM8B expression — UCEC

Explore this box plot interactively →