TIMM8B

Across TCGA pan-cancer cohorts, TIMM8B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TIMM8B data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TIMM8B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIMM8B expression acts as an unfavorable survival marker, although some lineages such as OV and LUSC show a favorable association.

ACC, KICH, and UVM are the cancer types where TIMM8B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.259	0.682	<.001	144	view →
KICH	OS	Tertile	All	0.596	1.000	<.001	112	view →
UVM	DFS	Median	II,III,IV	0.331	0.691	.001	81	view →
LIHC	OS	Median	All	0.372	0.711	<.001	48	view →
OV	OS	Median	III,IV	0.380	0.264	.001	44	view →
LUSC	OS	Median	All	0.461	0.326	.007	30	view →
HNSC	DFS	Tertile	All	0.236	0.400	.001	30	view →
PAAD	DFS	Median	All	0.405	0.592	.004	28	view →
LAML	DFS	Quartile	All	0.348	0.716	.003	26	view →
LGG	OS	Tertile	All	0.864	0.954	<.001	24	view →
UCS	DFS	Tertile	IV	0.361	0.932	.024	24	view →
SKCM	DFS	Median	All	0.660	0.848	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TIMM8B–ACC (DFS)

Open the ACC breakdown →