translocase of inner mitochondrial membrane 23 homolog BGenealiases: []
Q-omics provides the consensus-scored TIMM23B profile across patient tissues and cancer cell-line models. TIMM23B expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TIMM23B is differentially expressed in 9, with the highest sampling consensus in THCA. Additionally, TIMM23B RNA expression shows 21,062 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and THCA as cancer lineages where TIMM23B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TIMM23B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TIMM23B survival associations across molecular data types. TIMM23B RNA expression shows survival associations in the most cancer types (27), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TIMM23B RNA expression–survival associations across cancer types. High TIMM23B expression shows unfavorable associations in ACC, THCA and KIRC, but favorable associations in LGG, UCS and LUAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TIMM23B RNA expression.
This table summarizes TIMM23B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for TIMM23B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TIMM23B shows lower tumor expression in THCA, KICH and KIRC and higher tumor expression in COAD, LUAD and CHOL. The THCA box plot shows higher TIMM23B RNA expression in normal versus tumor tissue (log2 FC = −0.376, t-test p < 0.001).
This table shows molecular features associated with TIMM23B in patient tissues and cancer cell lines. In patient samples, TIMM23B shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TIMM23B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia.
