Across TCGA pan-cancer cohorts, TIMM23B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TIMM23B data layer compared with 27 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TIMM23B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TIMM23B expression acts as an unfavorable survival marker.

STAD, COAD, and SKCM are the cancer types where TIMM23B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
COAD	OS	Median	All	0.202	0.806	.006	12	view →
SKCM	DFS	Median	All	0.087	0.757	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TIMM23B tumor-vs-normal RNA expression · all TIMM23B data types