THOC3

Across TCGA patient cohorts, THOC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,158 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THOC3-associated proteins across cancer lineages are MCM2, MCM2_S139, and MCM3. Each is linked with THOC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both THOC3-to-partner and partner-to-THOC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THOC3 versus MCM2 in GBM, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC3→partner) and Y-score (partner→THOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM2 →	+0.725	+0.458	<.001	<.001	3	8
LUAD	MCM2_S139 →	+0.830	+0.525	<.001	.002	3	8
GBM	MCM3 →	+0.712	+0.383	<.001	<.001	3	8
GBM	MCM6 →	+0.840	+0.489	<.001	<.001	3	8
GBM	MCM7 →	+0.751	+0.453	<.001	<.001	3	8
GBM	SMC4 →	+0.640	+0.470	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,158 associations by consensus.

THOC3 vs MCM2 — GBM

Explore this scatter interactively →