THOC3

Across TCGA pan-cancer cohorts, THOC3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of THOC3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where THOC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THOC3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where THOC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THOC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.093	<.001	10	view →
KIRC	Male	All	+0.425	<.001	10	view →
LUAD	Male	III,IV	+1.118	<.001	9	view →
LIHC	Male	II,III,IV	+0.856	<.001	9	view →
STAD	All	All	+0.732	<.001	9	view →
LUSC	Female	II,III,IV	+2.105	<.001	8	view →
BLCA	Male	III,IV	+1.488	<.001	8	view →
HNSC	Male	All	+0.828	<.001	8	view →
KIRP	Male	II,III,IV	+0.723	<.001	7	view →
UCEC	All	II,III,IV	+1.074	<.001	6	view →
BRCA	All	III,IV	+1.024	<.001	6	view →
KICH	Female	All	−0.800	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

THOC3–COAD

Open the COAD breakdown →