Q-omics provides the consensus-scored TDH profile across patient tissues and cancer cell-line models. TDH expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, TDH is differentially expressed in 9, with the highest sampling consensus in THCA. Additionally, TDH RNA expression shows 15,995 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, THCA, and UVM as cancer lineages where TDH shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TDH — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TDH survival associations across molecular data types. TDH RNA expression shows survival associations in the most cancer types (20), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TDH RNA expression–survival associations across cancer types. High TDH expression shows unfavorable associations in UVM and ACC, but favorable associations in HNSC, KIRP, LGG and CESC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify HNSC as the clearest survival context for TDH RNA expression.
This table summarizes TDH tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for TDH. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TDH shows lower tumor expression in THCA, KICH, COAD and KIRP and higher tumor expression in HNSC and CHOL. The THCA box plot shows higher TDH RNA expression in normal versus tumor tissue (log2 FC = −1.664, t-test p < 0.001).
This table shows molecular features associated with TDH in patient tissues and cancer cell lines. In patient samples, TDH shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
