TDH

Across TCGA patient cohorts, TDH mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDH-associated genes across cancer lineages are eIF4E, ERK2, and INPP4B. Each is linked with TDH in more than 1 cancer types. Because this analysis shows association rather than direction, both TDH-to-partner and partner-to-TDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TDH-low versus TDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDH→partner) and Y-score (partner→TDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.245	+2.321	.021	.035	3	1
UCEC	ERK2 →	+0.199	+2.321	.040	.035	3	1
UCEC	INPP4B →	-0.324	-2.999	.046	.035	3	1
UCEC	mTOR_pS2448 →	-0.172	-2.321	.021	.035	3	1
UCEC	ATM →	-0.573	-2.321	.011	.035	3	1
UCEC	Caspase-8 →	-0.270	-3.295	.032	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by TDH expression — UCEC

Explore this box plot interactively →